منابع مشابه
Regulation of Bone Metabolism
Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...
متن کاملregulation of bone metabolism
bone is formed through the processes of endochondral and intramembranous ossification. in endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (mscs) differentiate directly into osteoblasts to form bone. the steps of osteogenic proliferation, differentiation,...
متن کاملThe cell biology of bone metabolism.
Contrary to the commonly held misconception, bone is a relatively dynamic organ that undergoes significant turnover as compared to other organs in the body. This review details how complex intercellular signalling, between the osteoprogenitor cells and mature osteoblasts, osteocytes and osteoclasts, regulates and balances activities of bone cells during remodelling and growth. Both systemic, as...
متن کاملSH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion
IGF-1 and insulin promote β-cell expansion by inhibiting β-cell death and stimulating β-cell proliferation, and the phosphatidylinositol (PI) 3-kinase/Akt pathway mediates insulin and IGF-1 action. Impaired β-cell expansion is a risk factor for type 2 diabetes. Here, we identified SH2B1, which is highly expressed in β-cells, as a novel regulator of β-cell expansion. Silencing of SH2B1 in INS-1 ...
متن کاملCaffeine and Osteoporosis: Effects of Caffeine on Bone Cell Metabolism
Jui-Sheng Sun, MD., Ph.D. 1, 3 Yang-Hwei Tsuang, MD., Ph.D. 2 Shih-I Lai, BS. 3 Hongsen Chiang MD. 3 Li-Ting Chen, M.S. 3 and Feng-Huei Lin, Ph.D. 4,5 1 Department of Orthopedic Surgery, Yun-Lin Hospital, Department of Health, The Executive Yuan, Yuan-Lin County, Taiwan, R.O.C. 2 Department of Orthopedic Surgery, China Medical College Hospital, Taichung, Taiwan, R.O.C. 3 Department of Orthopedi...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2001
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/16.6.1108